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# The Role of Human Growth Hormone (HGH) in Muscle Gain Human growth hormone (HGH) is a peptide hormone produced by the pituitary gland that plays a key role in tissue growth, metabolism, and repair. In recent decades, it has attracted the attention of bodybuilders and athletes as a means of increasing muscle mass. However, it is important to understand how [hgh muscle growth](https://alliedbioscience.com/does-hgh-make-you-gain-weight/), the mechanisms underlying its action, and the risks associated with its use. ![https://muscleandhealth.com/wp-content/uploads/2022/01/bodybuild.jpeg](https://muscleandhealth.com/wp-content/uploads/2022/01/bodybuild.jpeg) **HGH's Mechanism of Action on Muscle** HGH's primary effect on muscle is through stimulation of insulin-like growth factor 1 (IGF-1) production in the liver. IGF-1, in turn, activates signaling pathways that promote muscle fiber hypertrophy and an increase in their number—a process known as hyperplasia. HGH also directly affects muscle cells by activating the MAPK/ERK pathway, which promotes cell division and growth. The Effect of HGH on Body Composition HGH use can lead to an increase in lean body mass and a decrease in body fat percentage. This is due to increased lipolysis (fat breakdown) and stimulation of muscle protein synthesis. However, it is important to note that weight gain with HGH use is often associated not only with muscle growth but also with fluid retention (Verywell Fit). **The Effectiveness of HGH in Bodybuilding** While HGH can promote muscle gain, its effectiveness in bodybuilding is limited. Research shows that when HGH is used without accompanying training and proper nutrition, muscle gains may be minimal. Furthermore, the increase in mass may be due to fluid retention rather than actual muscle growth (Verywell Fit). **Conclusion** Human growth hormone (HGH) plays an important role in regulating growth and metabolism. While its use can promote muscle gain, its effectiveness is limited and depends on many factors, including diet, training, and individual characteristics. Furthermore, HGH use is associated with a number of side effects and health risks. Therefore, before deciding to use HGH, it is necessary to consult a doctor and carefully weigh all possible consequences.